Response surface method for optimization of prepared satranidazole powder layered pellets

Abstract Background The purpose of the present study was to evaluate layered satranidazole powder using natural polysaccharides as coating materials for colon targeting that were inexpensive and with a non-toxic nature composite response design 3 levels 2 factors each four responses in quadratic model. independent variables ratio consistency % (X1) level (X2) pellet. dependent release drug at h. (Y1), 6 (Y2), difference presence & absence colonic enzyme (Y3) mean dissolution time (Y4). various models fitted an explanation suitable statistical methods. Variance analysis different factor constructed by surface plots. Results Satranidazole pellets efficiently prepared variable amount ingredients showed compatibility possible pellet characterization profiles optimize formulation. Conclusions strategy can be successful tool improving which appropriate replacement regular one.